Mast cell degranulation in periodontal disease from HIV-infected individuals
Braz. j. oral sci
; 18: e191445, jan.-dez. 2019. ilus
Article
en En
| LILACS, BBO
| ID: biblio-1094900
Biblioteca responsable:
BR218.1
ABSTRACT
Aim:
The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART).Methods:
Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and tained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained.Results:
No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups.Conclusions:
There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
BBO
/
LILACS
Asunto principal:
Enfermedades Periodontales
/
VIH
/
Periodontitis Crónica
/
Gingivitis
/
Mastocitos
/
Mucosa Bucal
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. oral sci
Asunto de la revista:
ODONTOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil