ELISA saliva for trypanosoma cruzi antibody detection: An alternative for serological surveys in endemic regions
Am. j. trop. med. hyg
; Am. j. trop. med. hyg;102(4): 800-803, Apr. 2020. ilus
Article
en En
| SES-SP, SESSP-IIERPROD, SES-SP
| ID: biblio-1095179
Biblioteca responsable:
BR31.1
Ubicación: BR31.1; 2020_P-012
ABSTRACT
Chagas is a neglected disease endemic in Latin America. Vector transmission control had been aggressively performed. Recent entomological surveillance in Brazil has revealed natural infection rates ranging from 0.40% to 0.52%. Although serological surveys are complex to develop, they are important for disease control. In this study, we validated the use of saliva in ELISA commercial kits with a cohort of 100 patients with Chagas disease followed at Hospital das Clinicas in São Paulo, Brazil, and 50 healthy controls. Five ELISA kits for detecting antibodies against Trypanosoma cruzi were tested. The best discrimination between Chagas patients and controls was observed with the Wiener kit, which yielded a sensitivity of 97% and a specificity of 100%. Our findings reveal that the use of saliva may be an alternative to large-scale screening surveys in detecting T. cruzi antibodies; it is a noninvasive sample collection method potentially key to large-scale screening in children
Texto completo:
1
Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-IIERPROD
Asunto principal:
Trypanosoma cruzi
/
Brasil
/
Enfermedad de Chagas
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Am. j. trop. med. hyg
Año:
2020
Tipo del documento:
Article