Prospects for new leprosy diagnostic tools, a narrative review considering ELISA and PCR assays
Rev. Soc. Bras. Med. Trop
; 53: e20200197, 2020.
Artículo
en Inglés
| Sec. Est. Saúde SP, Coleciona SUS, LILACS
| ID: biblio-1143857
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract Slit skin smear and histopathological examinations are currently the main laboratory tools used to aid the diagnosis of leprosy. However, their sensitivity is low, and many cases are not detected. New methodologies have been studied to develop more accurate tests. This narrative review aims to raise attention to the results of molecular (polymerase chain reaction) and serological (Enzyme-Linked Immunosorbent Assay) tests applied to the diagnosis of leprosy, and to summarize the available information about the former. Original scientific articles published in indexed international journals, whose study involved aspects of the diagnosis and classification of leprosy cases or home contacts, were selected. The data were extracted independently using a standardized method that dictated the inclusion of the following information diagnosis in Paucibacillary and Multibacillary cases and in household contacts; sample number; sample type; study design; studied variables; statistical analysis employed; main results; and limitations identified. In clinical practice, the results from molecular and serological tests are assessed separately, with moderate sensitivity and specificity. However, an integrated study of these methodologies has been suggested for greater accuracy in diagnosis.
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
Brasil
Contexto en salud:
Enfermedades Desatendidas
Problema de salud:
Lepra
/
Enfermedades Desatendidas
Base de datos:
LILACS
/
Sec. Est. Saúde SP
/
Coleciona SUS
Asunto principal:
Lepra
/
Mycobacterium leprae
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. Soc. Bras. Med. Trop
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Universidade Federal de Juiz de Fora/BR
/
Universidade Vale do Rio Doce/BR