Activation and regulation of toll-like receptors 2 and 1 in human leprosy
s.l; s.n; 2003. 8 p. ilus, graf.
Non-conventional
en En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1241191
Biblioteca responsable:
BR191.1
Ubicación: [{"text": "BR191.1", "_a": "09113/s"}]
ABSTRACT
The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell activation by killed M. leprae, indicating the presence of triacylated lipoproteins. A genome-wide scan of M. leprae detected 31 putative lipoproteins. Synthetic lipopeptides representing the 19-kD and 33-kD lipoproteins activated both monocytes and dendritic cells. Activation was enhanced by type-1 cytokines and inhibited by type-2 cytokines. In addition, interferon (IFN)-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression. TLR2 and TLR1 were more strongly expressed in lesions from the localized tuberculoid form (T-lep) as compared with the disseminated lepromatous form (L-lep) of the disease. These data provide evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens.
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Colección:
06-national
/
BR
Base de datos:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Asunto principal:
Glicoproteínas de Membrana
/
Citocinas
/
Receptores de Superficie Celular
/
Inmunidad Innata
/
Lepra
/
Lipoproteínas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2003
Tipo del documento:
Non-conventional
Pais de publicación:
Estados Unidos