Therapeutic use of human papillomavirus vaccines in cervical lesions
Rev. invest. clín
; 72(4): 239-249, Jul.-Aug. 2020. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-1251861
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Human papillomavirus (HPV) has been associated with the development of precancerous lesions of the cervix and cervical cancer (CC). Prophylactic HPV vaccination induces the development of a specific memory immune response that facilitates HPV elimination once the natural infection occurs. At present, in addition to the prophylactic vaccine, therapeutic vaccines are being developed and researched with the aim of inducing an immune response that allows the elimination of HPV-infected cells. The purpose of this study is to describe the current evidence on the use of therapeutic vaccines and their effect on cervical precancerous lesions, to establish recommendations on their clinical use. So far, the studies that have generated results have described a marginal beneficial effect of the prophylactic vaccine in the management of infection and pre-invasive lesions. Based on the evidence, continuing research on the efficacy and safety of therapeutic vaccines for the treatment of cervical intraepithelial lesions is recommended. The use of the HPV prophylactic vaccine as treatment for pre-existing lesions is not advised, but it is recommended to prevent new lesions.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Contexto en salud:
ODS3 - Salud y Bienestar
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
Base de datos:
LILACS
Asunto principal:
Lesiones Precancerosas
/
Neoplasias del Cuello Uterino
/
Infecciones por Papillomavirus
/
Vacunas contra Papillomavirus
Tipo de estudio:
Guía de práctica clínica
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. invest. clín
Asunto de la revista:
Medicina
Año:
2020
Tipo del documento:
Artículo
País de afiliación:
India
/
México
Institución/País de afiliación:
Centro Estatal de Cancerología de Nayarit/MX
/
Centro Médico ABC/MX
/
Hospital General de México Dr. Eduardo Liceaga,/MX
/
Instituto Nacional de Cancerología/MX
/
Instituto Nacional de Perinatología/MX