Intima-media thickness of femoral arteries and carotids among an adult hypertensive Nigerian population: a casecontrol study to assess their use as surrogate markers of atherosclerosis
Ann. afr. med
; 18(3): 158-166, 2019.
Article
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| AIM
| ID: biblio-1258912
Biblioteca responsable:
CG1.1
ABSTRACT
Background:
Increased intima-media thickness (IMT) is an established and important surrogate marker for atherosclerosis. Intima-media thickening in the femoral arteries occur earlier and reflect the true extent of generalized atherosclerosis better than in the carotids.Aims:
To study the ultrasound-detected morphological changes in the common femoral versus carotid artery wall. Patients andMethods:
A case-control study design was used, with 61 adult hypertensive as cases and 61 age-, sex- and BMI-matched normotensive as controls. Variables were participants' characteristics, cardiovascular risk factors, and ultrasonographically evaluated IMT of the carotid and femoral arteries.Results:
A total of 122 participants were studied. The mean femoral IMT in hypertensives and controls on the right and left was 0.63 ± 0.07mm vs. 0.52 ± 0.06mm [P < 0.0001] and 0.69 ± 0.0 mm vs. 0.55 ± 0.05mm [P < 0.0001]. Also, the mean carotid IMT among hypertensives and controls on the right =0.80 ±0.15mm vs. 0.64 ± 0.06mm [P < 0.0001], and 0.91 ± 0.22mm vs. 0.65 ± 0.06mm [P < 0.0001] on the left. Significant correlation was observed between IMT and age (B = 0.006, P < 0.001 and B = 0.003, P < 0.001), hypertension (B = 0.205, P < 0.001 and B = 0.122, p<0.001), and duration of hypertension (B = 0.02, P < 0.001 and B = 0.006, P = 0.02) the femoral and carotid arteries respectively.Conclusion:
The femoral and the carotid artery show similar significantly increased IMT in hypertensive adults. The femoral IMT appears to be a good surrogate marker of atherosclerosis among hypertensive Nigerians
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Base de datos:
AIM
Asunto principal:
Adulto
/
Arteria Femoral
/
Grosor Intima-Media Carotídeo
/
Hipertensión
/
Nigeria
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
País/Región como asunto:
Africa
Idioma:
En
Revista:
Ann. afr. med
Año:
2019
Tipo del documento:
Article