The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects
Libyan j. med
; 4(3): 97-103, 2009. figures
Article
en En
| AIM
| ID: biblio-1265095
Biblioteca responsable:
CG1.1
ABSTRACT
Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may result in death. Inflammation describes a coordinated series of molecular; cellular; tissue; organ; and systemic responses that drive the pathology of various diseases including T/HS and traumatic brain injury (TBI). Inflammation is a finely tuned; dynamic; highly-regulated process that is not inherently detrimental; but rather required for immune surveillance; optimal post-injury tissue repair; and regeneration. The inflammatory response is driven by cytokines and chemokines and is partially propagated by damaged tissue-derived products (Damage-associated Molecular Patterns; DAMP's). DAMPs perpetuate inflammation through the release of pro-inflammatory cytokines; but may also inhibit anti-inflammatory cytokines. Various animal models of T/HS in mice; rats; pigs; dogs; and non-human primates have been utilized in an attempt to move from bench to bedside. Novel approaches; including those from the field of systems biology; may yield therapeutic breakthroughs in T/HS and TBI in the near future. Key words Trauma; Hemorrhagic Shock; Taumatic Brain Injury; Inflammation; Systems Biology
Palabras clave
Texto completo
- https://indexmedicus.afro.who.int/iah/fulltext/The acute inflammatory response in trauma hemorrhage and traumatic brain injury current state and emerging prospects.pdf
- http://indexmedicus.afro.who.int/iah/fulltext/LJM/vol 4 n3/The Acute Inflammatory.pdf
- https://fi-admin.bvsalud.org/document/view/yn62e
Texto completo:
1
Base de datos:
AIM
Asunto principal:
Choque Hemorrágico
/
Hemorragia Encefálica Traumática
Límite:
Humans
Idioma:
En
Revista:
Libyan j. med
Año:
2009
Tipo del documento:
Article