Gut microbiota in Mexican patients with common variable immunodeficiency
Gac. méd. Méx
; 155(5): 447-452, Sep.-Oct. 2019. tab, graf
Article
en En
| LILACS
| ID: biblio-1286541
Biblioteca responsable:
BR1.1
ABSTRACT
Introduction:
Common variable immunodeficiency (CVID) is the main symptomatic primary immunodeficiency and is associated with complex immune disorders. Gut microbiota interacts closely with the immune system, and intestinal dysbiosis is related to multiple diseases.Objective:
To describe for the first time the composition of gut microbiota in Mexican patients with CVID.Methods:
Fecal samples from five patients with CVID were collected and massive sequencing of the V3-V4 region of 16S rRNA gene was carried out using illumina technology.Results:
Bacterial relative abundance was observed at all taxonomic levels. Firmicutes, Actinobacteria and Verrucomicrobia were the predominant phyla. The Clostridia class and the Clostridial order were the most common in their respective taxon; the Ruminococcaceae family predominated. A total of 166 genera were reported, with the most abundant being Faecalibacterium. Five species were identified, but only Bifidobacterium longum was present in all patients.Conclusions:
Unlike healthy subjects' gut microbiota, where Firmicutes and Bacteroidetes predominate, the microbiota of the patients with CVID considered in this study was abundant in Firmicutes, Actinobacteria and Verrucomicrobia. The low presence of Bacteroidetes and high abundance of Firmicutes might indicate the existence of intestinal dysbiosis in these patients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Inmunodeficiencia Variable Común
/
Microbioma Gastrointestinal
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Gac. méd. Méx
Asunto de la revista:
MEDICINA
Año:
2019
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
México