A survey of RNA viruses in mosquitoes from Mozambique reveals novel genetic lineages of flaviviruses and phenuiviruses, as well as frequent flavivirus-like viral DNA forms in Mansonia
BMC health serv. res. (Online)
; 20(226): 1-16, 2020. tab, mapas, ilus
Artículo
en Inglés
| RSDM
| ID: biblio-1358131
Biblioteca responsable:
MZ1.1
ABSTRACT
Background:
Mosquito-borne diseases involving arboviruses represent expanding threats to sub-Saharan Africa imposing as considerable burden to human and veterinary public health. In Mozambique over one hundred species of potential arbovirus mosquito vectors have been identi-fied, although their precise role in maintaining such viruses in circulation in the country remains to be elucidated. The aim of this study was to screen for the presence of flaviviruses, alphaviruses and bunyaviruses in mosquitoes from different regions of Mozambique.Results:
Our survey analyzed 14,519 mosquitoes, and the results obtained revealed genetically distinct insectspecific flaviviruses, detected in multiple species of mosquitoes from different genera. In addition, smaller flaviviruslike NS5 sequences, frequently detected in Mansonia seemed to correspond to defective viral sequences, present as viral DNA forms. Furthermore, three lineages of putative members of the Phenuiviridae family were also detected, two of which apparently corresponding to novel viral genetic lineages.Conclusion:
This study reports for the first-time novel insect-specific flaviviruses and novel phenuiviruses, as well as frequent flavivirus-like viral DNA forms in several widely known vector species. This unique work represents recent investigation of virus screening conducted in mosquitoes from Mozambique and an important contribution to inform the establishment of a vector control program for arbovirus in the country and in the region.
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
MZ
Base de datos:
RSDM
Asunto principal:
Bunyaviridae
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ADN Viral
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Alphavirus
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Flavivirus
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Mosquitos Vectores
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Culicidae
Límite:
Animales
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
BMC health serv. res. (Online)
Año:
2020
Tipo del documento:
Artículo
Institución/País de afiliación:
Faculty of medicine, eduardo mondlane university (UEM)/MZ
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Faculty of veterinary sciences pretoria, university of pretoria (up)/ZA
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Faculty of veterinary, eduardo mondlane university (uem)/MZ
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Instituto nacional de saúde/MZ
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Universidade nova de lisboa (nova), and global health and tropical medicine (ghtm)+PT
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Universidade nova de lisboa (nova), and global health and tropical medicine (ghtm)+PT