Pain management & opioid dose reduction with topical sevoflurane instillations in intractable venous ulcers: a case report
Braz. J. Pharm. Sci. (Online)
; 58: e18681, 2022. graf
Artículo
en Inglés
| LILACS
| ID: biblio-1360162
Biblioteca responsable:
BR40.1
Ubicación: BR40.1
ABSTRACT
Abstract Vascular ulcers (VU) constitute a major cause of pain and disability, and significantly compromise quality of life. VU have a natural tendency to become chronic and in many cases exhibit anunsatisfactoryresponse to many of the standard therapeutic options.The case of a 73 year-old Caucasian female with severe pain and poorly-controlled pain (Visual Analogic Scale-VAS- of 8-9) due to three lower leg long-standing VUs is reported and discussed herein. The patient was treated with topical instillations of undiluted sevoflurane as per institutional off-label protocol (starting doses of 1mL/cm2 twice a day, and up-titrated according to response to a maximum of 7 mL twice daily). The VAS score dropped to 0-1 shortly after initiation of therapy and remained stable throughout treatment up until the closure of the observations. Subsequently, opioid therapy was gradually tapered down and ultimately abandoned.Sevoflurane application resulted on adequate and sustained pain management of refractory VU, with no significant side effects. On account of its beneficial effectivity and safety profiles, topical sevoflurane emerges as an add-on alternative for the long-term management of VU, and potentially other painful conditions.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Contexto en salud:
Agenda de Salud Sostenible para las Américas
/
ODS3 - Salud y Bienestar
/
ODS3 - Meta 3.5 Prevención y tratamiento del consumo de sustancias psicoactivas
Problema de salud:
Objetivo 9: Enfermedades no transmisibles y salud mental
/
Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles
/
Meta 3.5: Prevención y tratamiento del consumo de sustancias psicoactivas
/
Abuso de Opióides
Base de datos:
LILACS
Asunto principal:
Dolor
/
Úlcera Varicosa
/
Informe de Investigación
/
Sevoflurano
/
Reducción Gradual de Medicamentos
/
Analgésicos Opioides
Tipo de estudio:
Guía de práctica clínica
Aspecto:
Preferencia del paciente
Límite:
Anciano
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
España
Institución/País de afiliación:
Public Health Agency of Poniente/ES
/
Torrecárdenas University Hospital/ES