Pediatric Heart Transplant: Initial Experience in a Tertiary Center in Brazil
Rev. bras. cir. cardiovasc
; 37(3): 281-291, May-June 2022. tab, graf
Article
en En
|
LILACS-Express
| LILACS
| ID: biblio-1376534
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Introduction:
Pediatric heart transplantation is the definitive therapy for children with end-stage heart failure. This paper describes our initial experience in pediatric heart transplantation in a tertiary center in BrazilMethods:
This is a historical prospective descriptive cohort study based on a review of the medical records of children undergoing heart transplantation at Hospital de Base and Hospital da Criança e Maternidade de São José do Rio Preto. Variables were displayed as frequency, mean, or median. Statistical analysis and Kaplan-Meier actuarial curve were obtained with the aid of Microsoft® Excel® 2019 and STATSDirect version 3.3.5.Results:
Between January 2010 and December 2020, ten children underwent bicaval orthotopic heart transplantation, 30% of which were under one year of age. Nine patients had end-stage heart failure (International Society for Heart and Lung Transplantation-Heart Failure D) and 50% of the recipients were transplanted under conditions of progressive clinical deterioration (Interagency Registry for Mechanically Assisted Circulatory Support ≤ 2). Forty percent of the recipients had a panel-reactive antibody > 20% on virtual crossmatch. In the postoperative period, 80% of patients required high dose of inotropic support (vasoactive-inotropic score > 10) for > 48 hours. The death-free survival rate at 131 months was 77.1±14.4%. Most patients (88.9%) in late follow-up had an episode of active cytomegalovirus infection. Cellular rejection, with or without clinical repercussion, was present in 44.4% of the patients.Conclusion:
Pediatric heart transplantation produces acceptable and feasible outcomes as definitive therapy for children with end-stage heart failure.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Tipo de estudio:
Observational_studies
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. bras. cir. cardiovasc
Asunto de la revista:
CARDIOLOGIA
/
CIRURGIA GERAL
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil