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Evaluation of copaiba oil as enhancer of ibuprofen skin permeation
Nogueira, Rodrigo José Lupatini; Grazul, Richard Michael; Silva Filho, Ademar Alves Da; Nascimento, Jorge Willian Leandro.
Afiliación
  • Nogueira, Rodrigo José Lupatini; Federal University of Juiz de Fora. Faculty of Pharmacy. Department of Pharmaceutical Sciences. Juiz de Fora. BR
  • Grazul, Richard Michael; Federal University of Juiz de Fora. Institute of Exact Sciences. Department of Chemistry. Juiz de Fora. BR
  • Silva Filho, Ademar Alves Da; Federal University of Juiz de Fora. Faculty of Pharmacy. Department of Pharmaceutical Sciences. Juiz de Fora. BR
  • Nascimento, Jorge Willian Leandro; Federal University of Juiz de Fora. Institute of Biological Sciences. Department of Pharmacology. Juiz de Fora. BR
Braz. J. Pharm. Sci. (Online) ; 58: e19548, 2022. tab, graf
Article en En | LILACS | ID: biblio-1384013
Biblioteca responsable: BR40.1
Ubicación: BR40.1
ABSTRACT
Abstract The administration of medications on the skin through transcutaneous routes is a practice that has been used by mankind for millennia. Some studies have been reporting the use of terpenes and natural oils rich in terpenes as an enhancer of cutaneous penetration. Copaiba oil, due to its rich content of terpenes, presents itself as a great choice of penetration enhancer for drugs administered on the skin. In this study, we developed two cream formulations containing 5% of ibuprofen (IBU) and copaiba oil IBCO5 and IBCO10 with 5% and 10% of copaiba oil respectively. Ex vivo cutaneous penetration/permeation studies of IBU were performed using pig ear skin as biological membrane in the Franz-type diffusion cells. The steady-state flux of IBU samples, IBCO5 (35.72 ± 6.35) and IBCO10 (29.78 ± 2.41) were significantly higher when compared with control without copaiba oil (10.32 ±1.52) and with a commercial product (14.44 ± 2.39). In the penetration analysis, the amount of IBU found in the samples IBCO5 and IBCO10 was markedly higher in the dermis than epidermis. Our results showed that copaiba oil possesses attracting properties in promoting skin penetration and permeation of IBU when added into cream formulations.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Piel / Extractos Vegetales / Ibuprofeno / Fabaceae Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Piel / Extractos Vegetales / Ibuprofeno / Fabaceae Idioma: En Revista: Braz. J. Pharm. Sci. (Online) Asunto de la revista: Farmacologia / Terapˆutica / Toxicologia Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil