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Association of recurrent upper respiratory tract infections with low production of oxygen intermediates in children
Calapodopulos, Natália Vieira Inácio; Sawan-Mendonça, Mônica Miguel; Silva, Marcos Vinicius da; Oliveira, Carlo Jose Freire; Weffort, Virgínia Resende; Rodrigues, Denise Bertululucci Rocha; Rodrigues Jr, Virmondes.
Afiliación
  • Calapodopulos, Natália Vieira Inácio; Universidade Federal do Triângulo Mineiro (UFTM). Departamento Materno Infantil. Uberaba. BR
  • Sawan-Mendonça, Mônica Miguel; Universidade Federal do Triângulo Mineiro (UFTM). Departamento de Imunologia, Microbiologia e Parasitologia. Uberaba. BR
  • Silva, Marcos Vinicius da; Universidade Federal do Triângulo Mineiro (UFTM). Departamento de Imunologia, Microbiologia e Parasitologia. Uberaba. BR
  • Oliveira, Carlo Jose Freire; Universidade Federal do Triângulo Mineiro (UFTM). Departamento de Imunologia, Microbiologia e Parasitologia. Uberaba. BR
  • Weffort, Virgínia Resende; Universidade Federal do Triângulo Mineiro (UFTM). Departamento Materno Infantil. Uberaba. BR
  • Rodrigues, Denise Bertululucci Rocha; Universidade Federal do Triângulo Mineiro (UFTM). Departamento de Imunologia, Microbiologia e Parasitologia. Uberaba. BR
  • Rodrigues Jr, Virmondes; Universidade Federal do Triângulo Mineiro (UFTM). Departamento de Imunologia, Microbiologia e Parasitologia. Uberaba. BR
J. pediatr. (Rio J.) ; 98(4): 399-405, July-Aug. 2022. tab, graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1386109
Biblioteca responsable: BR1.1
ABSTRACT
Abstract Objectives: Upper respiratory tract infections in children generally have significant morbidity and mortality. There is little data available about functional immaturity of the immune system and the child's susceptibility to infections at the beginning of their lives, thus, justifying a more specific immunological analysis. Method: Analysis of hemograms and innate and adaptive immune responses in 95 children between age 1 to 6 years with episodes of recurrent respiratory infections (test group n = 39) and without these episodes (control group n = 56) was carried out. The production of reactive oxygen intermediates by peripheral blood cells stimulated by phorbol myristate acetate was analyzed. Additionally, the number of B lymphocytes, auxiliary T lymphocytes, and cytotoxic cells was determined using flow cytometry. Results: Results from both groups did not show statistically significant differences in red blood cells, total leukocytes count, and the differential neutrophils, eosinophils, basophils, lymphocytes, and monocytes count. The analysis of the number of B lymphocytes, auxiliary T lymphocytes (LTCD4), and cytotoxic cells (LTCD8) also did not show any difference between both groups. However, the production of radical oxygen intermediates was significantly reduced in the test group as compared to the control group (p < 0.05). Conclusions: There was no difference in the analysis of hemograms, leukograms, or the number of lymphocytes, LTCD4, LTCD8, or LTCD19. The reduced production of oxygen intermediates in the affected group suggests that these children's microbicide capacity is compromised, which may be related to their recurrent respiratory infections.


Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: ODS3 - Salud y Bienestar / ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles Problema de salud: Meta 3.2: Evitar muertes en recién nacidos y niños menores de 5 años / Otras Enfermedades Respiratorias Base de datos: LILACS Tipo de estudio: Factores de riesgo Idioma: Inglés Revista: J. pediatr. (Rio J.) Asunto de la revista: Pediatría Año: 2022 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Triângulo Mineiro (UFTM)/BR

Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: ODS3 - Salud y Bienestar / ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles Problema de salud: Meta 3.2: Evitar muertes en recién nacidos y niños menores de 5 años / Otras Enfermedades Respiratorias Base de datos: LILACS Tipo de estudio: Factores de riesgo Idioma: Inglés Revista: J. pediatr. (Rio J.) Asunto de la revista: Pediatría Año: 2022 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Triângulo Mineiro (UFTM)/BR
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