Novavax COVID-19 vaccine local reactions, systemic reactions, adverse events, and serious adverse events

ABSTRACT

Local reactions were reported by the majority of vaccine recipients and at higher rates than placebo recipients (75.3% vs 20.6% after dose 2). Pain/tenderness at the injection site was the most common and most severe local reaction among vaccine recipients and reported more frequently after dose 2 than after dose 1. Injection site redness and swelling following either dose were reported less frequently but were more common after dose 2 than dose 1. There were no grade 4 local reactions reported. Overall the median time to onset for local reactions was 1-3 days. The median duration of local reactions was 1-3 days in the vaccine group.