Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil
ABCS health sci
; 47: e022306, 06 abr. 2022. ilus, tab, mapas
Article
en En
| LILACS
| ID: biblio-1402636
Biblioteca responsable:
BR1342.1
Ubicación: BR1342.1
ABSTRACT
Pseudomonas aeruginosa is one of the main microorganisms causing healthcarerelated infections. The rise of carbapenem-resistant P. aeruginosa (CRPA) strains has become a serious public health problem. Dissemination of the enzyme Klebsiella pneumoniae carbapenemase (KPC) encoded by the blaKPC gene cause the inactivation of ß-lactam antibiotics being one of the mechanisms involved in this resistance. Given the above, the objective of this review was to evaluate the occurrence of the blaKPC gene in clinical isolates of P. aeruginosa in Brazil. For this, the online databases used were Lilacs, SciELO and PubMed. The search for articles included articles published from 2012 to 2020, using the following keywords blaKPC (KPC), Pseudomonas aeruginosa, and Brazil (in Portuguese and English). Initially, 30 publications eligible for inclusion in this review were identified. After the first analysis, two articles were excluded due to duplication. Subsequently, titles and abstracts were evaluated, 15 articles were excluded because they did not fit the theme, and 13 articles that met the inclusion criteria were read in full. In these studies, the presence of the blaKPC gene was investigated in 566 clinical isolates of P. aeruginosa in Brazil, with 86 (15.2%) positive samples found. Pernambuco was the state with the highest number of articles and positive samples, respectively, 38.5% (5/13), and 65.1% (56/86). This study reinforces the need to investigate the occurrence of this gene in all regions of the country in CRPA, aiming to understand how its dissemination occurs and to promote prevention and therapeutic strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Pseudomonas aeruginosa
/
Enterobacteriaceae Resistentes a los Carbapenémicos
/
Klebsiella pneumoniae
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
ABCS health sci
Asunto de la revista:
MEDICINA
/
SAUDE PUBLICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil