The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
Rev. Inst. Med. Trop. São Paulo (Online)
; 64: e64, 2022. graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1406891
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
LILACS
Tipo de estudio:
Estudio de etiología
Idioma:
Inglés
Revista:
Rev. Inst. Med. Trop. São Paulo (Online)
Asunto de la revista:
Medicina Tropical
Año:
2022
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR