Chronic medical conditions associated with invasive pneumococcal diseases in inpatients in teaching hospitals in São Paulo city: Estimating antimicrobial susceptibility and serotype-coverage of pneumococcal vaccines
Braz J Infect Dis
; 27(6)2023.
Artículo
en Inglés
| LILACS, CONASS, Coleciona SUS, Sec. Est. Saúde SP, SESSP-IALPROD, Sec. Est. Saúde SP
| ID: biblio-1417653
Biblioteca responsable:
BR91.2
Ubicación: BR91.2; P
ABSTRACT
Background:
Chronic conditions increase the risk of invasive pneumococcal diseases (IPD). Pneumococcal vaccination remarkably reduced IPD morbimortality in vulnerable populations. In Brazil, pneumococcal vaccines are included in the National Immunization Program (PNI) PCV10 for < 2 years-old, and PPV23 for high risk-patients aged ≥ 2 years and institutionalized ≥ 60 years. PCV13 is available in private clinics and recommended in the PNI for individuals with certain underlying conditions.Methods:
A retrospective study was performed using clinical data from all inpatients from five hospitals with IPD from 2016 to 2018 and the corresponding data on serotype and antimicrobial-non-susceptibility of pneumococcus. Vaccine-serotype-coverage was estimated. Patients were classified according to presence of comorbidities healthy, without comorbidities; at-risk, included immunocompetent persons with specific medical conditions; high-risk, with immunocompromising conditions and othersRESULTS:
406 IPD cases were evaluated. Among 324 cases with information on medical conditions, children < 5 years were mostly healthy (55.9%), while presence of comorbidity prevailed in adults ≥ 18 years old (> 82.0%). Presence of ≥1 risk condition was reported in ≥ 34.8% of adults. High-risk conditions were more frequent than at-risk in all age groups. Among high-risk comorbidity (n = 211), cancer (28%), HIV/AIDS (25.7%) and hematological diseases (24.5%) were the most frequent. Among at-risk conditions (n = 89), asthma (16.5%) and diabetes (8.1%) were the most frequent. Among 404 isolates, 42.9% belonged to five serotypes 19A (14.1%), 3 (8.7%), 6C (7.7%), 4 and 8 (6.2% each); 19A and 6C expressed antimicrobial-non-susceptibility. The vaccine-serotype-coverage was PCV10, 19.1%, PCV13, 43.8%; PCV15, 47.8%; PCV20, 62.9%; PCV21, 65.8%, and PPV23, 67.3%. Information on hospital outcome was available for 283 patients, of which 28.6% died. Mortality was 54.2% for those with meningitis.Conclusion:
Vaccine with expanded valence of serotypes is necessary to offer broad prevention to IPD. The present data contribute to pneumococcal vaccination public health policies for vulnerable patients, mainly those with comorbidity and the elderly. Keywords Antimicrobial resistance; Chronic diseases; Comorbidity; Invasive pneumococcal diseases; Pneumococcal conjugate vaccine; Pneumococcal serotypes; Pneumococcal vaccine.
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
Brasil
Contexto en salud:
ODS3 - Salud y Bienestar
/
Enfermedades Desatendidas
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ODS3 - Meta 3.3 Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
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ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
/
ODS3 - Meta 3.2 Evitar muertes en recién nacidos y niños menores de 5 años
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
/
Meta 3.2: Evitar muertes en recién nacidos y niños menores de 5 años
/
Enfermedades Desatendidas
/
Zoonosis
/
SIDA
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Meningitis
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Neumonía
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Asma
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Otras Enfermedades Respiratorias
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Infecciones
Base de datos:
CONASS
/
LILACS
/
Sec. Est. Saúde SP
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SESSP-IALPROD
/
Coleciona SUS
Asunto principal:
Asma
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Streptococcus pneumoniae
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VIH
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Vacunas Conjugadas
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Meningitis
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Idioma:
Inglés
Revista:
Braz J Infect Dis
Año:
2023
Tipo del documento:
Artículo
Institución/País de afiliación:
Centro de Bacteriologia, Laboratório Nacional de Meningite e Infecção Pneumocócica, Instituto Adolfo Lutz (IAL) São Paulo/BR
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Faculdade de Ciências Médicas da Santa Casa de São Paulo/BR
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Hospital Sírio-Libanês, Instituto de Ensino e Pesquisa, São Paulo/BR
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Hospital Universitário (HU) da Universidade de São Paulo (USP) São Paulo/BR
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Hospital do Servidor Público Estadual (HSPE) São Paulo/BR
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Instituto de Infectologia Emílio Ribas (IIER) São Paulo/BR
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03) Hospital das Clínicas da Universidade de São Paulo (HCUSP) São Paulo+BR
/
Sociedade Brasileira de Imunizações (SBim) São Paulo/BR