Hereditary thrombophilia and low -molecular -weight heparin in women: useful determinants, including thyroid dysfunction, incorporating the management of treatment and outcomes of the entity
Rev. Assoc. Med. Bras. (1992, Impr.)
; 69(2): 335-340, Feb. 2023. tab, graf
Artículo
en Inglés
|
LILACS-Express
| LILACS
| ID: biblio-1422627
Biblioteca responsable:
BR1.1
ABSTRACT
SUMMARY OBJECTIVE: Our study purposed to examine the complex relationship between low-molecular-weight heparin therapy, multiple pregnancy determinants, and adverse pregnancy outcomes during the third trimester in women with inherited thrombophilia. METHODS: Patients were selected from a prospective cohort of 358 pregnant patients recruited between 2016 and 2018 at the Clinic for Obstetrics and Gynecology, University Clinical Centre of Serbia, Belgrade. RESULTS: Gestational age at delivery (β=-0.081, p=0.014), resistance index of the umbilical artery (β=0.601, p=0.039), and D-dimer (β=0.245, p<0.001) between 36th and 38th weeks of gestation presented the direct predictors for adverse pregnancy outcomes. The model fit was examined using the root mean square error of approximation 0.00 (95%CI 0.00-0.18), the goodness-of-fit index was 0.998, and the adjusted goodness-of-fit index was 0.966. CONCLUSION: There is a need for the introduction of more precise protocols for the assessment of hereditary thrombophilias and the need for the introduction of low-molecular-weight heparin.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
LILACS
Tipo de estudio:
Guía de práctica clínica
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Rev. Assoc. Med. Bras. (1992, Impr.)
Asunto de la revista:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicina
Año:
2023
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Turquía
Institución/País de afiliación:
General Hospital Novi Pazar/RS
/
Giresun Üniversitesi/TR
/
Universidade de São Paulo/BR
/
University Clinical Center of Serbia/RS
/
Univerzitet u Beogradu/RS