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Determinants of visit-to-visit systolic blood pressure variability among Ghanaians with hypertension and diabetes mellitus
Sarfo, Fred S; Ayisi-Boateng, Nana K; Nguah, Samuel B; Sarfo-Kantanka, Osei; Kokuro, Collins; Ababio, Hanson; Adu-Boakye, Yaw; Ovbiagele, Bruce.
Afiliación
  • Sarfo, Fred S; Kwame Nkrumah University of Science and Technology. Kumasi. GH
  • Ayisi-Boateng, Nana K; Kwame Nkrumah University of Science and Technology. Kumasi. GH
  • Nguah, Samuel B; Kwame Nkrumah University of Science and Technology. Kumasi. GH
  • Sarfo-Kantanka, Osei; Kwame Nkrumah University of Science and Technology. Kumasi. GH
  • Kokuro, Collins; Kwame Nkrumah University of Science and Technology. Kumasi. GH
  • Ababio, Hanson; Kwame Nkrumah University of Science and Technology. Kumasi. GH
  • Adu-Boakye, Yaw; Kwame Nkrumah University of Science and Technology. Kumasi. GH
  • Ovbiagele, Bruce; University of California, San Francisco. California. US
Ghana med. j ; 57(1): 1-9, 2023. tables
Article en En | AIM | ID: biblio-1427093
Biblioteca responsable: CG1.1
ABSTRACT

Objective:

To identify the determinants of systolic blood pressure variability (SBPV) among Ghanaians.

Design:

We undertook a secondary analysis of data collected in a prospective study

Setting:

The study involved patients with hypertension and or diabetes receiving care in five hospitals in Ghana Main outcome

measures:

We assessed determinants of SBPV among 2,785 Ghanaian patients. We calculated the standard deviation (SD) of systolic BP recordings of 3 to 10 visits per patient over 18 months as a measure of SBPV. A multivariate linear regression analysis was fitted to identify factors independently associated with risk visit-to-visit SBP standard deviation.

Results:

The mean SD of individual patient visit-to-visit SBP overall was 14.8±6.3 mm Hg. Those with hypertension and diabetes had the highest SD of 15.4 ±6.2 mm Hg followed by 15.2 ±6.5 mm Hg among those with hypertension only and then 12.0 ± 5.2 mm Hg among those with diabetes only, p<0.0001. Factors independently associated with SBPV with adjusted ß coefficients (95% CI) included age 0.06 (0.03 ­ 0.08) for each year rise in age, eGFR -0.03 (-0.05 - -0.02) for each ml/min rise, low monthly income of <210 Ghana cedis 1.45 (0.43-2.46), and secondary level of education -1.10 (-1.69, -0.50). Antihypertensive classes were associated with SBPV, the strongest associations being hydralazine 2.35 (0.03 ­ 4.68) and Methyldopa 3.08 (2.39 ­ 3.77).

Conclusion:

Several socio-demographic and clinical factors are associated with SBPV. Future studies should assess the contribution of SBPV to CVD outcomes among indigenous Africans and identify actionable targets.
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Texto completo: 1 Base de datos: AIM Asunto principal: Presión Sanguínea / Diabetes Mellitus / Hipertensión Maligna Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ghana med. j Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: AIM Asunto principal: Presión Sanguínea / Diabetes Mellitus / Hipertensión Maligna Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ghana med. j Año: 2023 Tipo del documento: Article