Emergence of Neisseria meningitidis W South American sublineage strain variant in Brazil: disease and carriage
J Med Microbiol .
; 71(2)2022.
Artículo
en Inglés
| CONASS, Coleciona SUS, Sec. Est. Saúde SP, SESSP-IALPROD, Sec. Est. Saúde SP
| ID: biblio-1427695
Biblioteca responsable:
BR91.2
Ubicación: BR91.2; P
ABSTRACT
Introduction. Invasive meningococcal disease is a major health problem, impacting morbidity and mortality worldwide. Exploratory genomics has revealed insights into adaptation, transmissibility and virulence to elucidate endemic, outbreaks or epidemics caused by Neisseria meningitidis serogroup W (MenW) strains.Gap Statement. Limited information on the genomics of Neisseria meningitis serogroup W ST11/cc11 is available from emerging countries, especially in contemporary isolates.Aim. To (i) describe the antigenic diversity and distribution of genetic lineages of N. meningitidis serogroup W circulating in Brazil; (ii) study the carriage prevalence of hypervirulent clones in adolescents students and (iii) analyse the potential risk factors for meningococcal carriage.Methodology. Using whole-genome sequencing, we analysed the genomic diversity of 92 invasive N. meningitidis serogroup W isolates circulating in Brazil from 2016 to 2019. A cross-sectional survey of meningococcal carriage was conducted in 2019, in the city of Florianópolis, Brazil, among a representative sample of 538 students.Results. A predominance (58.5 %, 41/82) of ST11/cc11 presenting PorB2-144, PorA VR1-5, VR2-2, FetA 1-1, and a novel fHbp peptide 1241 was found on invasive N. meningitidis W isolates, on the other hand, a high diversity of clonal complexes was found among carriage isolates. The overall carriage rate was 7.5 % (40/538). A total of 28 of 538 swab samples collected were culture positive for N. meningitidis, including four serogroup/genogroup B isolates (14.8 %;4/27), 1 serogroup/genogroup Y isolate (3.7 %;1/27), 22 (81.5 %; 22/27) non-groupable isolates. No MenW isolate was identified among carriages isolates.Conclusion. This report describes the emergence of the new MenW ST11/cc11 South America sublineage variant, named here, 2016 strain, carrying a novel fHbp peptide 1241, but its emergence, was not associated with an increased MenW carriage prevalence. Continuous surveillance is necessary to ascertain the role of this sublineage diversification and how its emergence can impact transmission.
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
Brasil
Base de datos:
CONASS
/
Sec. Est. Saúde SP
/
SESSP-IALPROD
/
Coleciona SUS
Asunto principal:
Esguinces y Distensiones
/
Enfermedad
/
Neisseria meningitidis
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
J Med Microbiol .
Año:
2022
Tipo del documento:
Artículo
Institución/País de afiliación:
Centro de Bacteriologia/BR
/
Centro de Imunologia/BR
/
Coordenação Geral de Emergências em Saúde Pública/BR
/
Faculdade de Medicina da Santa Casa de São Paulo/BR
/
Laboratório Estratégico/BR
/
Laboratório de Saúde Pública de Santa Catarina/BR
/
Universidade Federal de Santa Catarina/BR
/
Vigilância Epidemiológica de Santa Catarina/BR