Mechanical dispersion is a superior echocardiographic feature to predict exercise capacity in preclinical and overt heart failure with preserved ejection fraction
Int. j. cardiovasc. imaging
; 39(7)Mar. 2023.
Artículo
en Inglés
| CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1428596
Biblioteca responsable:
BR79.1
ABSTRACT
BACKGROUND:
Heart Failure with Preserved Ejection Fraction (HFpEF) is a syndrome characterized by different degrees of exercise intolerance, which leads to poor quality of life and prognosis. Recently, the European score (HFA-PEFF) was proposed to standardize the diagnosis of HFpEF. Even though Global Longitudinal Strain (GLS) is a component of HFA-PEFF, the role of other strain parameters, such as Mechanical Dispersion (MD), has yet to be studied. In this study, we aimed to compare MD and other features from the HFA-PEFF according to their association with exercise capacity in an outpatient population of subjects at risk or suspected HFpEF.METHODS:
This is a single-center cross-sectional study performed in an outpatient population of 144 subjects with a median age of 57 years, 58% females, referred to the Echocardiography and Cardiopulmonary Exercise Test to investigate HFpEF.RESULTS:
MD had a higher correlation to Peak VO2 (r=-0.43) when compared to GLS (r=-0.26), MD presented a significant correlation to Ventilatory Anaerobic Threshold (VAT) (r=-0.20; p = 0.04), while GLS showed no correlation (r=-0.14; p = 0.15). Neither MD nor GLS showed a correlation with the time to recover VO2 after exercise (T1/2). In Receiver Operator Characteristic (ROC) analysis, MD presented superior performance to GLS to predict Peak VO2 (AUC 0.77 vs. 0.62), VAT (AUC 0.61 vs. 0.57), and T1/2 (AUC 0.64 vs. 0.57). Adding MD to HFA-PEFF improved the model performance (AUC from 0.77 to 0.81).CONCLUSION:
MD presented a higher association with Peak VO2 when compared to GLS and most features from the HFA-PEFF. Adding MD to the HFA-PEFF improved the model performance.
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Colección:
Bases de datos nacionales
/
Brasil
Base de datos:
CONASS
/
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Asunto principal:
Ecocardiografía
/
Prueba de Esfuerzo
/
Insuficiencia Cardíaca Diastólica
/
Insuficiencia Cardíaca
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Aspecto:
Preferencia del paciente
Idioma:
Inglés
Revista:
Int. j. cardiovasc. imaging
Año:
2023
Tipo del documento:
Artículo
Institución/País de afiliación:
Biomedical Engineering Laboratory, University of São Paulo/BR
/
Brazilian National Laboratory for Biosciences, Brazilian Center for Research in Energy and Materials (CNPEM)/BR
/
Instituto Dante Pazzanese de Cardiologia/BR