Estudo bibliométrico da produção científica da atividade antifúngica dos compostos químicos gamma-terpineno, terpinene-4-ol e sabineno / Bibliometric study of the scientific production of the antifungal activity of the chemical compounds gamma-terpinene, terpinene-4-ol and sabinene

RESUMO

Este trabalho teve como objetivo conhecer a produção científica sobre a atividade antifúngica dos compostos químicos gamma-terpineno, terpinene-4-ol e sabineno, de óleos essenciais. Trata-se de um estudo descritivo, exploratório de abordagem quantitativa, realizado por meio de revisão da literatura, onde foi possível mapear a produtividade científica dos compostos bioativos citados. A busca foi realizada em fevereiro de 2021, abordando o período de 1964 a 2020, utilizando a fonte de informação PubMed/MEDLINE. Na pesquisa livre os termos gamma-terpinene and antifungal, terpinene-4-ol and antifungal e sabinene and antifungal e no MeSH Database - Medical Subject Heading Terms (Mesh Terms ­ MeSH) desenvolvido pela U.S National Library of Medicine, utilizando os termos indexados gamma-terpinene and antifungal agents, terpinene-4-ol and antifungal agentes e sabinene and antifungal agents. Foram selecionados e analisados após os critérios de inclusão 192 artigos científicos. A análise foi realizada de forma descritiva com apresentação de frequências absolutas e relativas. O número de citações por artigo foi realizado no Google Acadêmico. Por meio do VOSViewer® foi analisado a rede de colaboração por coautoria e por coocorrência dos termos de pesquisa. A Banaras Hindu University, Universidade Estadual Paulista (UNESP), Universidade Federal do Ceará, Universidade de Coimbra...(AU)

ABSTRACT

This work aimed to know the scientific production on the antifungal activity of the chemical compounds gamma-terpinene, terpinene-4-ol and sabinene, in essential oils. This is a descriptive, exploratory study with a quantitative approach, carried out through a literature review, where it was possible to map the scientific productivity of the aforementioned bioactive compounds. The search was carried out in February 2021, covering the period from 1964 to 2020, using the information source PubMed/MEDLINE. In the free search the terms gamma-terpinene and antifungal, terpinene-4-ol and antifungal and sabinene and antifungal and in the MeSH Database - Medical Subject Heading Terms (Mesh Terms) developed by the US National Library of Medicine, using the indexed terms gamma -terpinene and antifungal agents, terpinene-4-ol and antifungal agents and sabinene and antifungal agents. 192 scientific articles were selected and analyzed after the inclusion criteria. The analysis was performed descriptively with the presentation of absolute and relative frequencies. The number of citations per article was performed on Google Scholar. Through VOSViewer®, the collaboration network was analyzed by co-authorship and by cooccurrence of the search terms. Banaras Hindu University, State University of São Paulo (UNESP), Federal University of Ceará, University of Coimbra and University of Belgrade, Serbia are the institutions that published the most in the period. Most authors developed the research in public institutions. Iran, India and Brazil were the countries that published the most. The most published journals are located in the United Kingdom and the United States. The most studied family of medicinal plants were Lamiaceae, Apiaceae and Myrtaceae. The most researched medicinal plants in terms of antifungal activity were Origanum vulgare L. (Oregano), Thymus vulgaris L. (Thyme), Rosmarinus officinalis L. (rosemary), Melaleuca alternifolia L. (Melaleuca), Origanum majorana L. (Marjoram). Candida albicans was the most studied species, followed by Aspergillus niger and Aspergillus flavus. The average life in years of selected articles in PubMed/MEDLINE - free search on gamma-terpinene was 6.5 years; 5-year terpinene-4-ol and 7-year sabinene and in the MeSH Database survey, 7-year gamma-terpinene, 5-year terpinene-4-ol and 8-year sabinene. The analysis of the correlation network by co-authorship and by co-occurrence of the terms used in the research of the selected articles, gamma-terpinene identified three clusters, terpinene-4-ol two clusters and sabinene only one cluster. Based on the analysis of this research with data indexed in the PubMed/MEDLINE information source, it was possible to identify a growth in the studies of chemical compounds isolated from essential oils. (AU