Extracorporeal photopheresis in chronic graft-versus-host disease: clinical description and economic study
Hematol., Transfus. Cell Ther. (Impr.)
; 45(2): 182-187, Apr.-June 2023. tab, ilus
Article
en En
| LILACS
| ID: biblio-1448352
Biblioteca responsable:
BR408.1
Ubicación: BR408.1
ABSTRACT
Abstract Introduction Although extracorporeal photopheresis (ECP) is a promising second-line therapy in the treatment of chronic graft-versus-host disease (cGVHD), its use is limited by its high cost. This study aims to describe the clinical evolution of patients who underwent ECP therapy for cGVHD and to perform an economic analysis of the therapy Methods This was a case series between 2016 and 2020 describing the clinical response to ECP and a micro-cost analysis of the therapy using time-driven activity-based costing. Results Six patients underwent ECP for corticosteroid-dependent cGVHD The cost per ECP session is 14,960.90 Brazilian reais (BRL), which primarily consists of the ECP kit with an activator (82.78%), followed by the hospital's physical structure (14.66%), human resources (2.48%) and exams/inputs (0.08%). The number of sessions performed ranged from 2 to 42. The total cost of the therapy per patient ranged from BRL 30,000 to 500,000. Conclusion The response of the patient with cGVHD to treatment with ECP was variable. These micro-costing results can be used to develop remuneration and cost control strategies in hematopoietic stem cell transplantation programs, as well as in further economic studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Fotoféresis
/
Enfermedad Injerto contra Huésped
Tipo de estudio:
Health_economic_evaluation
Aspecto:
Patient_preference
Límite:
Humans
Idioma:
En
Revista:
Hematol., Transfus. Cell Ther. (Impr.)
Asunto de la revista:
Hematologia
/
TransfusÆo de Sangue
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil