Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization

Zaniolo, Larissa Marchi; Damazo, Amílcar Sabino

Zaniolo, Larissa Marchi; Damazo, Amílcar Sabino.

Afiliación

Zaniolo, Larissa Marchi; Universidade do Estado de Mato Grosso. Faculdade de Ciências Agrárias, Biológicas, Engenharias e da Saúde. Tangará da Serra. BR
Damazo, Amílcar Sabino; Universidade Federal de Mato Grosso. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá. BR

Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;56: e0265, 2023. graf

Article en En | LILACS-Express | LILACS | ID: biblio-1521612

Biblioteca responsable: BR1.1

ABSTRACT

ABSTRACT

ABSTRACT While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.

Palabras clave

Immune response; Interleukin-17; Leprosy reaction; Leprosy

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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Idioma: En Revista: Jornal brasileiro de medicina tropical / Rev Soc Bras Med Trop / Rev. Soc. Bras. Med. Trop / Rev. Soc. Bras. Med. Trop. (Online) / Revista da Sociedade Brasileira de Medicina Tropical (Impresso) Asunto de la revista: MEDICINA TROPICAL Año: 2023 Tipo del documento: Article / Project document País de afiliación: Brasil Pais de publicación: Brasil

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