COVID-19 in hematopoietic stem cell transplant recipients during three years of the pandemic: a multicenter study in Brazil
Rev. Inst. Med. Trop. São Paulo (Online)
; 66: e17, 2024. tab, graf
Article
en En
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LILACS-Express
| LILACS
| ID: biblio-1550673
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR 101.01; 95% CI 8.205 - 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR 26.61; 95% CI 1.06 - 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Inst. Med. Trop. São Paulo (Online)
Asunto de la revista:
Medicina Tropical
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil