Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy
Rev. Soc. Bras. Med. Trop
; 50(2): 208-215, Mar.-Apr. 2017. tab, graf
Article
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| LILACS
| ID: biblio-842843
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar.METHODS:
Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level.RESULTS:
The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Significant differences were identified, which included hypochromic lesions predominantly in the BT clinical form (24%); diffuse-type lesions predominantly in the tuberculoid (TT) clinical form (28%); ill-defined lesion border dominance in lepromatous leprosy (LL) clinical forms (30%); an irregular lesion limit predominantly in LL clinical forms (32%); and a predominant Th1 immune response in the BT clinical form (41.7%).CONCLUSIONS:
The evaluation of the immunological profile in leprosy patients may contribute to the more detailed diagnosis and possibly better characterization of the prognosis for these individuals.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Células Th2
/
Células TH1
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Lepra Multibacilar
/
Lepra Paucibacilar
Tipo de estudio:
Observational_studies
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Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
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Screening_studies
Límite:
Adolescent
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Adult
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Female
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Humans
/
Male
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2017
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil