Farmacogenómica como herramienta fundamental para la medicina personalizada: aplicaciones en la práctica clínica / Clinical applications of pharmacogenomics
Rev. méd. Chile
; 145(4): 483-500, abr. 2017. tab
Article
en En
| LILACS
| ID: biblio-902502
Biblioteca responsable:
CL1.1
ABSTRACT
Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Farmacogenética
/
Polimorfismo Genético
/
Esquema de Medicación
Límite:
Humans
Idioma:
En
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Chile
Pais de publicación:
Chile