ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice
Clinics
; 73: e246, 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-952795
Biblioteca responsable:
BR1.1
ABSTRACT
OBJECTIVES:
The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene.METHODS:
Diabetic and non-diabetic mice harboring 2 or 3 copies of the angiotensin-converting enzyme gene were used in the present study. Animals were divided into 4 groups diabetic groups with two and three copies of the angiotensin-converting enzyme gene (2CD and 3CD) and the respective age-matched non-diabetic groups (2C and 3C). Hemodynamic, cardiovascular, and autonomic parameters as well as renal Ang II expression were evaluated.RESULTS:
Heart rate was lower in diabetic animals than in non-diabetic animals. Autonomic modulation analysis indicated that the 3CD group showed increased sympathetic modulation and decreased vagal modulation of heart rate variability, eliciting increased cardiac sympathovagal balance, compared with all the other groups. Concurrent diabetes and either angiotensin-converting enzyme polymorphism resulted in a significant increase in Ang II expression in the renal cortex.CONCLUSION:
Data indicates that a small increase in angiotensin-converting enzyme activity in diabetic animals leads to greater impairment of autonomic function, as demonstrated by increased sympathetic modulation and reduced cardiac vagal modulation along with increased renal expression of Ang II.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
LILACS
Asunto principal:
Sistema Nervioso Autónomo
/
Angiotensina II
/
Sistema Cardiovascular
/
Peptidil-Dipeptidasa A
/
Dosificación de Gen
/
Diabetes Mellitus Experimental
/
Riñón
Límite:
Animales
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundacao Universitaria de Cardiologia/BR
/
Universidade Federal de Sao Paulo/BR
/
Universidade Federal do Maranhao/BR
/
Universidade Mackenzie/BR
/
Universidade Sao Judas Tadeu/BR
/
Universidade de Campinas/BR
/
Universidade de Sao Paulo/BR