Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
Hematol., Transfus. Cell Ther. (Impr.)
; 40(2): 120-131, Apr.-June 2018. tab, graf, ilus
Article
en En
| LILACS
| ID: biblio-953824
Biblioteca responsable:
BR408.1
Ubicación: BR408.1
ABSTRACT
ABSTRACT Background:
Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.Methods:
This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters.Results:
The proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JAK2 V617F mutation was associated with high IP-10 levels in primary myelofibrosis patients.Conclusions:
Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Citocinas
/
Janus Quinasa 2
/
Leucemia Mieloide Crónica Atípica BCR-ABL Negativa
/
Inflamación
/
Trastornos Mieloproliferativos
/
Neoplasias
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Hematol., Transfus. Cell Ther. (Impr.)
Asunto de la revista:
Hematologia
/
TransfusÆo de Sangue
Año:
2018
Tipo del documento:
Article
País de afiliación:
Brasil