Comparing the Levels of Gingival Crevicular Fluid Prostaglandin E2 in Generalized Chronic Periodontitis Between Healthy and Type 2 Diabetes Patients: A Case-Control Study
Pesqui. bras. odontopediatria clín. integr
; 19(1): 4523, 01 Fevereiro 2019. tab, graf
Article
en En
| LILACS, BBO
| ID: biblio-998214
Biblioteca responsable:
BR1264.1
ABSTRACT
Objective:
To compare the prostaglandin E2 (PGE2) levels of gingival crevicular fluid in generalized chronic periodontitis between healthy and type 2 diabetic patients. Material andMethods:
56 diabetic and non-diabetic participants with generalized chronic periodontitis were selected randomly. They were divided into two groups (G1 generalized chronic periodontitis patients with normal blood sugar; and G2 generalized chronic periodontitis patients with diabetes). Gingival crevicular fluid samples were obtained from both groups. The average of 2 samples per day were centrifuged in a laboratory at 2500 rpm and temperature of 4°C for 5 minutes and placed in a refrigerator at -20°C. The level of PGE2 was measured using ELISA and Abcam kit. Data were analyzed by Kolmogorov-Smirnov, Mann-Whitney U Test, Pearson and independent T tests. The significant amount was considered 0.05 in this test (α<0.05).Results:
The mean level of PGE2 was significantly different in the two groups and the mean level of PGE2 in the control group was lower than the case group. There was no statistically significant relationship between PGE2 with pocket depth, fasting blood sugar (FBS) and HBA1C (p>0.05).Conclusion:
PGE2 level of diabetic patient group with chronic generalized periodontitis was significantly more than non-diabetic group with generalized chronic periodontitis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
BBO
/
LILACS
Asunto principal:
Higiene Bucal
/
Enfermedades Periodontales
/
Estudios de Casos y Controles
/
Diabetes Mellitus
/
Periodontitis Crónica
Tipo de estudio:
Observational_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Pesqui. bras. odontopediatria clín. integr
Asunto de la revista:
ODONTOLOGIA
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Brasil