Estudio farmacocinético de una dosis diaria de teofilina. / [The pharmacokinetic study of a daily dose of theophylline]
Medicina [B Aires]
; 52(6): 555-9, 1992.
Article
en Es
| BINACIS
| ID: bin-37939
Biblioteca responsable:
AR2.1
ABSTRACT
Theophylline pharmacokinetics, administered in tablets containing 600 mg in a sustained-release hydrophilic matrix for a once daily intake, was evaluated after being administered to 6 healthy volunteers during 7 days at 8 pm. Plasmatic levels at -2, 0, 2, 3, 4, 6, 8, 10, 12, 14, 18 and 24 hours in relation with 8 pm intake, were obtained at the 7th day of administration. A plasmatic curve was obtained with a maximum concentration at 12 hours of 10.18 mcg/ml, a minimum concentration of 3.27 mcg/ml and an area under the concentration/time curve of 198.4 mcg.h/ml. These data make it evident that the tablet studied shows a release profile without excessive peaks and an average concentration at steady state within therapeutical range, and suggests its use in asthma.
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Colección:
06-national
/
AR
Base de datos:
BINACIS
Idioma:
Es
Revista:
Medicina [B Aires]
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Argentina