Ensayo preclínico de la vacuna Candid #1 producida en Argentina contra la Fiebre Hemorrágica Argentina. / [Preclinical assay of candid #1 vaccine against Argentine Hemorrhagic Fever made in Argentina]
Medicina [B Aires]
; 65(4): 329-32, 2005.
Artículo
en Español
| BINACIS
| ID: bin-38261
Biblioteca responsable:
AR2.1
ABSTRACT
Candid #1 vaccine against Argentine Hemorrhagic Fever produced in USA versus lots of the same vaccine made in Argentina were compared in guinea pigs regarding safety, immunogenicity and protective efficacy against a challenge with pathogenic Junin virus. Lots No Exp 3, 7A and 8A of Argentine origin as well as lot TSI 5-1-92 from USA were inoculated in guinea pigs of 250-400 g in two consecutive assays. Ten animals inoculated with saline performed as normal controls in each experiment. Parameters studied were a) temperature; b) body weight; c) neutralizing antibodies to Junin virus; d) response to viral challenge. Animals gained weight and remained normothermic up to the challenge. Guinea pigs that received Candid #1 from any manufacturer elicited neutralizing antibodies to Junin virus (titles from 40 to 81920) and survived to challenge whilst 8/10 animals died in each control group. Data presented demonstrated that Candid #1 vaccines from USA or Argentine manufacturers were equally safe, immunogenic and protective in guinea pigs.
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Colección:
Bases de datos nacionales
/
Argentina
Base de datos:
BINACIS
País/Región como asunto:
America del Sur
/
Argentina
Idioma:
Español
Revista:
Medicina [B Aires]
Año:
2005
Tipo del documento:
Artículo