Hiperhomocisteinemia como factor de riesgo trombótico en pacientes con lupus eritematoso sistémico y síndrome antifosfolípido. / [Hyperhomocysteine like thrombocytic risk factor in patient with systemic lupus erythematous with antiphospholipid syndrome]

ABSTRACT

OBJECTIVES: to detect the prevalence of hyperhcy in SLE patients with and without antiphospholipid syndrom; to compare the Hcy levels between those patients and healthy controls and to determine the correlation between hyperhcy and antiphospholipid antibodies. PATIENTS AND METHODS: we studied 44 SLE patients 17 had antiphospholipid syndrom and 27 didnt have it, and we compared them to 24 healthy controls. All of them where checked clinically and with laboratory tests like anticardiolypin antibodies, lupus anticoagulant and Hcy. Hcy > 9 was considered abnormal. Patient who had hyperhcy were treated with folic acid+vitB6+vitB12 a month along. Statistical analysis: cualytative variables chi square or Fischers; cuantitative variables Students T test or Mann-Whitneys test. RESULTS AND CONCLUTIONS there were 35 trombotic manifestations in 44 patients. Hyperhcy was present in 27 SLE patients (61,4