La actividad transcripcional de NF-kappaB es diferencialmente regulada por dominios específicos del coactivador TIF2. / [Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-kappaB transactivation]

ABSTRACT

We have previously shown that nuclear receptor coactivator overexpression significantly enhanced NF-kappaB activity in a dose response manner. We studied the mechanism by which TIF2 regulates NF-kappaB activity. We determined that 1) the p38 specific inhibitor reduces 50