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Capacidad ácidosupresora del omeprazol 20 mg comprimidos versus pantoprazol 20 y 40 mg comprimidos. Estudio piloto en voluntarios. / [Acid-supressing capacity of omeprazole 20 mg tablets vs pantoprazole 20 and 40 mg tablets. A pilot study in volunteers]
Corti, R; Améndola, R; Menéndez, Graciela; Diwecj, Judith; Schenone, Liliana; Soutric, J; Caruso, N.
Afiliación
  • Caruso, N; Unidad de Esófago y Estómago. Dpto. Medicina Hospital de Gastroenterología Dr. C. Bonorino Udaondo, Ciudad de Buenos Aires, Argentina. rodolfocorti@hotmail.com.
Acta gastroenterol. latinoam ; 33(4): 199-203, 2003.
Article en Es | BINACIS | ID: bin-38809
Biblioteca responsable: AR40.1
ABSTRACT

OBJECTIVE:

To compare the acid-supressing capacity of omeprazole (OZ) 20 mg tablets vs pantoprazole (PZ) 20 and 40 mg tablets, in healthy volunteers, with 24-h intragastric pH-metry. MATERIAL AND

METHODS:

Open, randomized, cross-over trial in 10 healthy volunteers; on days 0.8 and 22, 24-h intragastric pH-metry. Day 0, basal, thereafter 7 days with OZ or PZ 20 mg/day; day 8, pH-metry, then [quot ]wash out[quot ] for 7 days and thereafter 7 more days therapy with PZ or OZ. On day 22 a 24-h intragastric pH control was performed again. In the last treatment stage, all of them were administered pantoprazole 40 mg/day for 8 days again with a 24-h pH recording at the end.

RESULTS:

24-h pH-metry expressed as the time (hours) in which the pH was < or = 4 and the values as mean +/- standard deviation. BASAL 22.12 +/- 1.54, POST-OZ 9.78 +/- 6.72, POST-PZ 20 15.65 +/- 5.65, POST-PZ 40 8.57 +/- 5.93. Statistical evaluation with two way repeated measures ANOVA p < 0.0001. Newman Keuls post-hoc test (1) vs (2) p < 0.003; (1) vs (3) p < 0.03; (2) vs (4) 0.65.

CONCLUSIONS:

According to the results it might be stated that both proton pump inhibitors have acid-supressing capacity and omeprazole in equal dosis is more effective than pantoprazole as acid-supressor, with statistically significative differences. There was no difference between 20 mg omeprazole and 40 mg pantoprazole.
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Colección: 06-national / AR Base de datos: BINACIS Tipo de estudio: Clinical_trials Idioma: Es Revista: Acta gastroenterol. latinoam Año: 2003 Tipo del documento: Article
Buscar en Google
Colección: 06-national / AR Base de datos: BINACIS Tipo de estudio: Clinical_trials Idioma: Es Revista: Acta gastroenterol. latinoam Año: 2003 Tipo del documento: Article