Aislamiento del virus de la coriomeningitis linfocitaria de seres humanos / Isolation of lymphocytic choriomeningitis virus from human individuals
Medicina [B.Aires]
; 61(6): 837-42, 2001. maps, tab, gra
Artículo
en Español
| BINACIS
| ID: bin-9235
Biblioteca responsable:
BR1.1
ABSTRACT
The activity of lymphocytic choriomeningitis virus (LCMv) in Argentina has been previously reported on the basis of serological evidence in rodents and humans and the isolation of only one strain of LCMv from a Mus domesticus captured in the province of Cordoba. The aim of this paper was to register patients with serological diagnosis of LCM, to isolate and to identify human strains of LCMv in Argentina. During the last 19 years, 15 cases were diagnosed as LCM by immunoflourescent indirect assay (IFI) and enzyme-linked immunosorbent assay (ELISA) but when neutralizing assay (NT) was incorporated, eight cases were classified as confirmed, three as probable and four as negative. The geographic distribution of the cases included three provinces Cordoba, Buenos Aires and Santa Fe. Viral isolation was attempted in five patients classified as confirmed and only two resulted positive (P5226 and P8573). They were identified as LCMv by IFI and NT. The coexistence of LCMv with other arenaviruses, such as Junin and Oliveros viruses, in the same area, raises the probability of interactions between them, which could modify the virulence and/or pathogenicity for humans associated to genomic changes. Future studies of antigenic, genomic and virulence variability of different Argentine strains of LCMv, as well as the systematic search for human infection, will contribute to define the importance of this viral agent in our country and to implement control measures. (Au)
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Colección:
Bases de datos nacionales
/
Argentina
Base de datos:
BINACIS
Asunto principal:
Coriomeningitis Linfocítica
/
Virus de la Coriomeningitis Linfocítica
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
País/Región como asunto:
America del Sur
/
Argentina
Idioma:
Español
Revista:
Medicina [B.Aires]
Año:
2001
Tipo del documento:
Artículo
Institución/País de afiliación:
Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui/Argentina