Local synthesis of IgH subclasses in patients with Alzheimer's disease

ABSTRACT

Immunological studies have shown abnormalities of the humoral immune response in several Alzheimer's disease patients such as the increase of serie IgG. Eleven Alzheimer's disease patients were studied. Serum and cerebrospinal fluid were obtained simultaneously. Albumin and IgG subclasses were measured in both biological fluids by simple radial immunodiffusion. IgG subclasses intrathecal synthesis was were calculated by the improved hyperbolic function and CSF/serum quotient diagram of Reilber. Local IgG subclass synthesis in a varied number of patients were produced. IgG was synthesized in 6 patients and IgG in 4 patients. Seven patients showed local synthesized IgG, and 10 patients made IgG in central nervous system. No significant alterations were found in the age-relate blood brain barrier function. These results support the hypothesis about that an immune-dysregulation and/or autoimmunity mechanism may play an important role in the pathogenesis of the Alzheimer's disease(AU)