Single lesion paucibacillary leprosy: baseline profile of the Brazilian Multicenter Cohort Study
Int. j. lepr. other mycobact. dis
; 68(3): 247-257, Sept., 2000. tab, graf, map
Artículo
en Inglés
| Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1226954
Biblioteca responsable:
BR191.1
Ubicación: [{"text": "BR191.1"}]
ABSTRACT
In Brazil, there is little information about the clinical and epidemiological characteristics of paucibacillary, single skin lesion leprosy patients (SSL-PB). Only recently has the official notification system distinguished leprosy patients with a single lesion as a clinical entity, for whom the single-dose ROM (rifampin, ofloxacin and minocycline) regimen has been recommended. In this paper, we describe the baseline clinical features and the immunological background of a multicenter cohort of SSL-PB leprosy cases enrolled between December 1997-1998. Patients were recruited at health centers located in the following regions Southeast = Rio de Janeiro; North = Amazon and Rondônia states and Center-West = Goiás state. Eligible cases were newly detected, untreated single-lesion leprosy patients without thickened nerve involvement, and were assessed by clinical, bacilloscopic and histopathological exams. The Mitsuda skin test and anti-PGL-I serology (ELISA) were also performed. Of the 299 SSL-PB leprosy patients, 259 (86.6%) fulfilled the criteria for single-dose ROM intervention. Our results showed that patients recruited from different sites had similar features, considering the clinical and immunological profiles. There was a predominance of adults (mean age 32.4; S.D. = 16.0), and a BCG scar was detected in 76.7% of the children ( or = 5 mm) and seropositivity for anti-PGL-I was detected in 17.3% of the patients. These data are compatible with effective cell-mediated immunity and low bacillary load, suggesting favorable clinical outcomes for most SSL-PB participants of this cohort.
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
Brasil
Contexto en salud:
Enfermedades Desatendidas
Problema de salud:
Lepra
/
Enfermedades Desatendidas
Base de datos:
HANSEN
/
Hanseníase
/
Sec. Est. Saúde SP
/
SESSP-ILSLACERVO
Asunto principal:
Lepra Dimorfa
/
Lepra Lepromatosa
/
Lepra Tuberculoide
/
Lepra
Tipo de estudio:
Ensayo clínico controlado
/
Estudio de etiología
/
Estudio observacional
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Int. j. lepr. other mycobact. dis
Año:
2000
Tipo del documento:
Artículo
Institución/País de afiliación:
Fundação Oswaldo Cruz/BR
/
GWL Hansen´s Disease Center at Louisiana State University/US
/
Secretaria da Saúde de Porto Velho/BR
/
Universidade Federal de Goias/BR
/
Universidade Federal do Rio de Janeiro/BR
/
WHO Leprosy Reference Center/BR