Single lesion leprosy pacients multicentric cohort treated with single dose drug therapy: findings on three-year follow-up and public health perspective in Brazil
In. Universidade Federal do Rio de Janeiro.Instituto de Estudos em Saúde Coletiva. Investigações em sistema de saúde e controle da hanseníase. Rio de Janeiro, s.n, abr.-jun., 2008. p.363-376.
No convencional
en Inglés
| LILACS, Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1247260
Biblioteca responsable:
BR191.1
Ubicación: [{"text": "BR191.1", "_a": "01224/D.A"}]
ABSTRACT
Single skin lesion, paucibacillary (SSL-PB) leprosy is considered and early disease manifesation. This study the clinical outcome of a cohort of 259 newly diagnosed SSL-PB treated with one dose of rifampicin, ofloxacin, minocycline (ROM) and followed-up for three-years. Patients were recruited from the North, Central West and Southeast regions in Brazil (1997-2001). The result expected with ROM therapy was disappearance or the reduction of lesion size. Manifestation that required additional intervention were considered as poor clinical outcome:
type-1 reaction (T1R) with or without neuritis alone, increase in lesion size and shift from paucibacillary to multibacillary. The incidence of poor clinical outcome was calculated by person-month and with the Kaplan-Meier methods. 61.8% of the participants were females, mean age 32.2, and 67,2% had borderline tuberculoid (BT) or tuberculoid forms. T1R was the predominant event; shift from paucibacillary to multibacillaru was rare. 92.0% of the volunteers shown no events during the first year, the same occurring to 80.6% of them after 3 years of clinical monitoring. The probability of remaining event-free was highest among those 40 years old or younger. Poor outcome predominated among BT patients. Extended monitoring of SSL-PB leprosy cases under minimal therapy provided valuable case management information for reference centers.
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Colección:
Bases de datos nacionales
/
Brasil
Contexto en salud:
ODS3 - Salud y Bienestar
/
Enfermedades Desatendidas
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
/
Lepra
/
Enfermedades Desatendidas
Base de datos:
HANSEN
/
Hanseníase
/
LILACS
/
Sec. Est. Saúde SP
/
SESSP-ILSLACERVO
Asunto principal:
Dosis Única
/
Salud Pública
/
Lepra
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Aspecto:
Determinantes sociales de la salud
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Año:
2008
Tipo del documento:
No convencional
Institución/País de afiliación:
Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta/BR
/
Governo do Estado do Amazonas/BR
/
Hospital Dr. Marcello Cândia/BR
/
Instituto Oswaldo Cruz/BR
/
Secretária de Saúde de Rondônia/BR
/
Universidade Federal de Goiás/BR
/
Universidade Federal do Rio de Janeiro/BR
/
Universidade do Estado do Rio de Janeiro/BR