Wnt signalling and cancer stem cells
Clin. transl. oncol. (Print)
; 11(7): 411-427, jul. 2009. tab, ilus
Article
en En
| IBECS
| ID: ibc-123654
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefl y reviewed (AU)
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Células Madre
/
Células Madre Neoplásicas
/
Proteínas Wnt
/
Células Madre Pluripotentes Inducidas
/
Vía de Señalización Wnt
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Año:
2009
Tipo del documento:
Article