Oropharyngeal cancer related to Human Papilloma Virus: incidence and prognosis in Madrid, Spain
Clin. transl. oncol. (Print)
; 16(3): 301-306, mar. 2014.
Artículo
en Inglés
| IBECS
| ID: ibc-127738
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
PURPOSE:
To report the incidence of HPV-related oropharyngeal cancer (OC) in our region, and determine the influence of HPV status on survival among patients treated with chemoradiation (CRT).METHODS:
A total of 102 patients with stage II-IV OC treated by CRT at four hospitals in Madrid, Spain were retrospectively reviewed. Immunohistochemistry analysis was performed to evaluate p16 expression in pretreatment tumor block samples obtained from these patients. HPV-positive and HPV-negative patients were compared to assess differences in overall survival (OS), loco-regional control and disease-free survival.RESULTS:
Of the tumor samples evaluated, 26.7 % were p16 positive. HPV-positive patients were younger (median age, 56 vs 59 years; p = 0.052). No significant differences were observed in terms of tumor stage, gender, or smoking habit between HPV+ and HPV- patients. HPV+ patients showed a trend towards better OS (67.4, vs 49.7 %; hazard ratio, 0.55; p = 0.095).CONCLUSIONS:
Incidence of HPV-related OC in our region is similar to that reported in other regions in Europe, yet lower than in North America. We observed a trend for improved OS in patients with HPV+ oropharyngeal cancer (AU)RESUMEN
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Colección:
Bases de datos nacionales
/
España
Contexto en salud:
ODS3 - Salud y Bienestar
/
ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
/
Neoplasias de la Boca y Orofaríngea
Base de datos:
IBECS
Asunto principal:
Neoplasias Orofaríngeas
/
Infecciones por Papillomavirus
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Clin. transl. oncol. (Print)
Año:
2014
Tipo del documento:
Artículo
Institución/País de afiliación:
Hopsital Universitario Ramón y Cajal/Spain
/
Hospital Universitario Doce de Octubre/Spain
/
Hospital Universitario Puerta de Hierro/Spain
/
Hospital de la Princesa/Spain