Lung metastases in oligometastatic patients: outcome with stereotactic body radiation therapy (SBRT)
Clin. transl. oncol. (Print)
; 17(8): 668-672, ago. 2015. tab
Article
en En
| IBECS
| ID: ibc-138182
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Purpose. To assess the clinical results in terms of local control, toxicity, failure pattern and toxicity of SBRT in oligometastatic patients with inoperable lung metastases. Methods. Forty-four patients were treated (53 metastases). Dose regimen 5 × 12 Gy (66 %), 8 × 7.5 Gy (20.8 %) and 10 × 5 Gy (13.2 %). Response was assessed using PET/CT at 6 months after SBRT. Results. Local control at 1 and 2 years was 86.7 %. Seventy-five percent of local failures had received a BED <105 Gy. After a median follow-up of 13.3 months, 25 % experienced distant progression. Overall survival at 1 and 2 years was 86.7 and 60.4 %, and cancer-specific survival was 95.3 and 75.2 %, respectively. Grade 2 toxicity was 6.8 %. There was no grade 34 toxicity. Conclusion. SBRT is effective and safe. The main failure pattern is distant progression. The selection of patients with a high probability of remaining oligometastatic is crucial for the efficiency of SBRT, both clinically and in terms of resources (AU)
RESUMEN
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Radioterapia
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Pruebas Inmunológicas de Citotoxicidad
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Radiocirugia
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Muerte Celular
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Receptores del Factor de Necrosis Tumoral
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Neoplasias Pulmonares
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Metástasis de la Neoplasia
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Año:
2015
Tipo del documento:
Article