Lipodystrophies: adipose tissue disorders with severe metabolic implications
J. physiol. biochem
; 71(3): 471-478, sept. 2015. tab
Article
en En
| IBECS
| ID: ibc-142443
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Lipodystrophy encompass a group of heterogeneous disorders consisting in marked reduction, absence, and/or the redistribution of adipose tissue. Lipodystrophy is frequently complicated with severe insulin resistance, diabetes, hyperlipidemia, and fatty liver. Anatomically, lipodystrophies can be partial or generalized. Etiologically, they can be congenital or acquired. Lipodystrophy diagnosis can be challenging, and it has been suggested that partial forms can be easily misdiagnosed as common central obesity with associated metabolic syndrome. Conventional insulin-sensitizing approaches usually fail to fully ameliorate insulin resistance in lipodystrophic patients. Leptin replacement is an approved therapy for the metabolic complications of congenital generalized lipodystrophy. Novel nutritional interventions are promising complementary approaches for treating lipodystrophy metabolic complications
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Tejido Adiposo
/
Lipodistrofia
/
Enfermedades Metabólicas
Límite:
Humans
Idioma:
En
Revista:
J. physiol. biochem
Año:
2015
Tipo del documento:
Article