Cyclin D1 and Ki-67 expression correlates to tumor staging in tongue squamous cell carcinoma
Med. oral patol. oral cir. bucal (Internet)
; 20(6): e657-e663, nov. 2015. tab, ilus
Article
en En
| IBECS
| ID: ibc-144696
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
BACKGROUND:
The immunohistochemical expression of Cyclin D1 and Ki-67 were analyzed in tongue squamous cell carcinomas (SCC), relating them to the clinical and morphological exhibition of these tumors. MATERIAL ANDMETHODS:
Twenty-nine patients fulfilled the inclusion criteria; clinical data included gender, age, ethnicity and use of licit drugs such as alcohol and tobacco. The TNM staging and histopathological differentiation grading was assessed for each case. In addition, T1 patients were gathered with T2 patients; and T3 patients were gathered with T4 patients to assemble two distinct groups (T1/T2) and (T3/T4).RESULTS:
The mean follow-up time was 24 months and 30% of the patients died as a consequence of the disease, while 23.3% lived with the disease and 46.7% lived lesion-free. T1 and T2 tumors showed statistically lesser Ki-67 and Cyclin D1 staining when compared to T3 and T4 tumors.CONCLUSIONS:
Ki-67 and Cyclin D1 pose as auxiliary tools when determining the progression of tongue SCC at the time of diagnosis
Texto completo:
1
Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Neoplasias de la Lengua
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Inmunohistoquímica
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Carcinoma de Células Escamosas
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Antígeno Ki-67
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Genes bcl-1
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Med. oral patol. oral cir. bucal (Internet)
Año:
2015
Tipo del documento:
Article