The relationship between serum levels of vitamin D with asthma and its symptom severity: A case-control study
Allergol. immunopatol
; 44(6): 547-555, nov.-dic. 2016. tab, graf
Article
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| IBECS
| ID: ibc-157877
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
BACKGROUND:
Asthma is a heterogeneous disease characterised by chronic inflammatory airways, and is affected by several immunological factors. One of the most discussed and researched hypotheses is the relationship between vitamin D serum levels with asthma. This study aimed to investigate the relationship between vitamin D serum levels with asthma and pulmonary functions in children in Kurdistan province, Iran. MATERIALS ANDMETHODS:
In this case-control study, 120 children ranging from 6 to 18 years were referred in summer for investigation. Participants were divided into two groups asthma group, N=60; and control group, N=60. After serum separation, samples were analysed using vitamin D ELISA kit. Additionally, pulmonary function test and serum IgE levels were measured in both groups. Data were analysed using Chi-square test and multiple regression analysis in SPSS15.RESULTS:
No difference was shown between the groups in terms of gender composition (male 57.5; female 42.5) (P>0.05). Average Vitamin D serum level in the case group (17.98±8.68) was less than in control group (22.35±6.26) (P<0.01). In addition, the difference of vitamin D deficiency in level of suboptimal between the asthma (17.77±6.41) and the control group (24.9±3.18) was statistically significant (P<0.0001). Positive correlation existed between vitamin D levels with FEV1, FVC, and FEV1/FVC. Multiple regression analysis showed a reverse relationship between vitamin D levels with IgE serum levels; this remained after adjustment for potential confounders (e.g. age, sex, BMI, FEV1, and FVC).CONCLUSION:
The results showed that serum levels of vitamin D in asthma patients were less than in healthy people, and also reduced lung function in these patients. So, the serum levels of vitamin D in asthma patients must be checked continuouslyRESUMEN
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Asma
/
Vitamina D
/
Deficiencia de Vitamina D
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
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Female
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Humans
/
Male
Idioma:
En
Revista:
Allergol. immunopatol
Año:
2016
Tipo del documento:
Article