Spotlight on the relevance of mtDNA in cancer
Clin. transl. oncol. (Print)
; 19(4): 409-418, abr. 2017. tab, ilus
Article
en En
| IBECS
| ID: ibc-160889
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
The potential role of the mitochondrial genome has recently attracted interest because of its high mutation frequency in tumors. Different aspects of mtDNA make it relevant for cancers biology, such as it encodes a limited but essential number of genes for OXPHOS biogenesis, it is particularly susceptible to mutations, and its copy number can vary. Moreover, most ROS in mitochondria are produced by the electron transport chain. These characteristics place the mtDNA in the center of multiple signaling pathways, known as mitochondrial retrograde signaling, which modifies numerous key processes in cancer. Cybrid studies support that mtDNA mutations are relevant and exert their effect through a modification of OXPHOS function and ROS production. However, there is still much controversy regarding the clinical relevance of mtDNA mutations. New studies should focus more on OXPHOS dysfunction associated with a specific mutational signature rather than the presence of mutations in the mtDNA (AU)
RESUMEN
No disponible
Buscar en Google
Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Fosforilación Oxidativa
/
ADN Mitocondrial
/
Especies Reactivas de Oxígeno
/
Neoplasias
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Año:
2017
Tipo del documento:
Article