MicroRNA-148b is a potential prognostic biomarker and predictor of response to radiotherapy in non-small-cell lung cancer
J. physiol. biochem
; 72(2): 337-343, jun. 2016. tab, graf
Artículo
en Inglés
| IBECS
| ID: ibc-168277
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
miR-148b has been found to be aberrantly expressed in various tumor types. It has recently been reported to be involved in regulating radioresistance in non-small cell lung cancer (NSCLC) cells. However, its expression level and association with radiosensitivity in human patient samples have not been investigated. Real-time PCR was used to evaluate the expression levels of miR-148b. Χ2 test was performed to analyze the association between miR-148b expression levels and clinicopathological factors or radiosensitivity. Kaplan-Meier survival curve was constructed to estimate the overall survival (OS), and the differences in survival were compared using the log-rank test. Cox regression analysis was conducted to determine the prognostic value of miR-148b. The relative level of miR-148b was significantly decreased in NSCLC tissues compared with matched non-cancerous tissues (P < 0.0001), and it was higher in tissues of patients who are good responders compared to those who are poor responders to radiotherapy (P < 0.0001). Lower expression of miR-148b was positively associated with high tumor stage (P = 0.0407) and radioresistance (P = 0.0002), and it predicted poor survival in patients with (P = 0.0129) or without (P = 0.0094) radiotherapy treatment. miR-148b was an independent prognostic factor for NSCLC as demonstrated by Cox proportional hazards risk analysis. miR-148b may serve as a prognostic biomarker of poor survival and a novel predictor of response to radiotherapy treatment in NSCLC (AU)
RESUMEN
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Colección:
Bases de datos nacionales
/
España
Base de datos:
IBECS
Asunto principal:
ARN Neoplásico
/
Regulación hacia Abajo
/
Regulación Neoplásica de la Expresión Génica
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Carcinoma de Pulmón de Células no Pequeñas
/
MicroARNs
/
Pulmón
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Neoplasias Pulmonares
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J. physiol. biochem
Año:
2016
Tipo del documento:
Artículo
Institución/País de afiliación:
The First Hospital of Shijiazhuang/China
/
The Third Hospital of Hebei Medical University/China