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Characterisation of Two Polyketides from Streptomyces sp. SKH1-2 Isolated from Roots of Musa (ABB) cv. 'Kluai Sao Kratuep Ho'
Kuncharoen, Nattakorn; Fukasawa, Wataru; Iwatsuki, Masato; Mori, Mihoko; Shiomi, Kazuro; Tanasupawat, Somboon.
Afiliación
  • Kuncharoen, Nattakorn; Chulalongkorn University. Faculty of Pharmaceutical Sciences. Department of Biochemistry and Microbiology. Bangkok. Thailand
  • Fukasawa, Wataru; Kitasato University. Graduate School of Infection Control Sciences. Tokyo. Japan
  • Iwatsuki, Masato; Kitasato University. Kitasato Institute for Life Sciences. Tokyo. Japan
  • Mori, Mihoko; Kitasato University. Graduate School of Infection Control Sciences. Tokyo. Japan
  • Shiomi, Kazuro; Kitasato University. Kitasato Institute for Life Sciences. Tokyo. Japan
  • Tanasupawat, Somboon; Chulalongkorn University. Faculty of Pharmaceutical Sciences. Department of Biochemistry and Microbiology. Bangkok. Thailand
Int. microbiol ; 22(4): 451-459, dic. 2019. graf, tab
Artículo en Inglés | IBECS | ID: ibc-185063
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
An endophytic actinomycete strain SKH1-2 isolated from Musa (ABB) cv. 'Kluai Sao Kratuep Ho' collected in Suphan Buri province (14° 54′ 22.5″ N/100° 04′ 50″ E), Thailand, was identified as Streptomyces pseudovenezuelae based on phenotypic and chemotaxonomic characteristics, and 16S rRNA sequence analyses. A chemical investigation led to the isolation of two polyketide molecules from the n-butanol crude extract of the strain SKH1-2 culture broth. The compounds were purified using various chromatographic techniques and identified using spectroscopic methods compared with earlier published data. Compound 1, chartreusin, is known as an anti-Gram (+) bacterial compound and was active against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341 and Staphylococcus aureus ATCC 6538p with MIC values of 3.1, 1.6 and 12.5 μg/mL, respectively. Compound 2, lumichrome, did not show activity against all tested microbes. To our knowledge, this is the first report of chartreusin and lumichrome isolated from S. pseudovenezuelae. Taken together, it could be proved that Thai plant species are valuable reservoirs of interesting endophytic actinomycetes producing several interesting biologically active compounds
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Asunto(s)
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Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Staphylococcus aureus / Streptomyces / ARN Ribosómico 16S / Policétidos Idioma: Inglés Revista: Int. microbiol Año: 2019 Tipo del documento: Artículo Institución/País de afiliación: Chulalongkorn University/Thailand / Kitasato University/Japan
Buscar en Google
Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Staphylococcus aureus / Streptomyces / ARN Ribosómico 16S / Policétidos Idioma: Inglés Revista: Int. microbiol Año: 2019 Tipo del documento: Artículo Institución/País de afiliación: Chulalongkorn University/Thailand / Kitasato University/Japan
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