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Experimental rat model of chronic cerebral hypoperfusion-reperfusion mimicking normal perfusion pressure breakthrough phenomenon / Modelo experimental en rata de hipoperfusión cerebral crónica - reperfusión remedando el síndrome de restablecimiento de la presión de perfusión cerebral normal
Revuelta, Juan Manuel; Zamarrón, Álvaro; Fortes, José; Rodríguez-Boto, Gregorio; Vaquero, Jesús; Gutiérrez-González, Raquel.
Afiliación
  • Revuelta, Juan Manuel; Puerta de Hierro University Hospital. Department of Neurosurgery. Majadahonda. Spain
  • Zamarrón, Álvaro; La Paz University. Department of Neurosurgery. Madrid. Spain
  • Fortes, José; Helath Reserch Institute-Fundación Jiménez Díaz (IIS-FJD). Madrid. Spain
  • Rodríguez-Boto, Gregorio; Puerta de Hierro University Hospital. Department of Neurosurgery. Majadahonda. Spain
  • Vaquero, Jesús; Puerta de Hierro University Hospital. Department of Neurosurgery. Majadahonda. Spain
  • Gutiérrez-González, Raquel; Puerta de Hierro University Hospital. Department of Neurosurgery. Majadahonda. Spain
Neurocirugía (Soc. Luso-Esp. Neurocir.) ; 31(5): 209-215, sept.-oct. 2020. ilus, tab
Artículo en Inglés | IBECS | ID: ibc-195153
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT

BACKGROUND:

Normal perfusion pressure breakthrough (NPPB) phenomenon is a major life-threatening complication that restricts the treatment of complex intracranial arteriovenous malformations. The aim of the study it to develop a rat model mimicking NPPB phenomenon that enables the evaluation of any therapy to prevent such complication.

METHODS:

Twenty Wistar male rats were randomly assigned to either a study or a control group. Study animals underwent an end-to-side left external jugular vein-common carotid artery anastomosis and ligation of bilateral external carotid arteries. Control animals only underwent ligation of bilateral external carotid arteries. All animals were sacrificed sixty days after the procedure. Hemodynamic parameters [mean arterial pressure (MAP), intracranial pressure (ICP) and cerebral perfusion pressure (CPP)], blood-brain barrier (BBB) permeability (measured by fluorescein staining) and histological features were then compared between both groups.

RESULTS:

A significant decrease in MAP and CPP was confirmed in the study group. An increase in ICP was also observed. A significant decrease in MAP and CPP was also present in the study group when comparing preoperative values with those recorded on days 0 (postoperative), 7 and 60. Fluorescein staining findings were consistent with signs of BBB disruption in study animals. Histological analysis demonstrated an increased number of pyknotic neurons in the ipsilateral hemisphere of rat brains included in the study group.

CONCLUSION:

These results confirm that this model mimics a vascular steal state with chronic cerebral hypoperfusion comparable to patients with AVMs behavior and disruption of the BBB after fistula closure comparable to NPPB phenomenon disorders
Asunto(s)
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Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Presión Intracraneal / Malformaciones Arteriovenosas Intracraneales / Modelos Animales Límite: Animales Idioma: Inglés Revista: Neurocirugía (Soc. Luso-Esp. Neurocir.) Año: 2020 Tipo del documento: Artículo Institución/País de afiliación: Helath Reserch Institute-Fundación Jiménez Díaz (IIS-FJD)/Spain / La Paz University/Spain / Puerta de Hierro University Hospital/Spain
Buscar en Google
Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Presión Intracraneal / Malformaciones Arteriovenosas Intracraneales / Modelos Animales Límite: Animales Idioma: Inglés Revista: Neurocirugía (Soc. Luso-Esp. Neurocir.) Año: 2020 Tipo del documento: Artículo Institución/País de afiliación: Helath Reserch Institute-Fundación Jiménez Díaz (IIS-FJD)/Spain / La Paz University/Spain / Puerta de Hierro University Hospital/Spain
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