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Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas
Soares, Ciro Dantas; Hernandez-Guerrero, Juan Carlos; Andrade, Bruno Augusto; Romañach, Mário José; Mosqueda-Taylor, Adalberto; Carlos, Román; Macedo, Madja Ruanna; Almeida, Oslei Paes de; Jorge, Jacks.
Afiliación
  • Soares, Ciro Dantas; University of Campinas. Piracicaba Dental School. Area of Pathology. Departament of Oral Diagnosis. São Paulo. Brazil
  • Hernandez-Guerrero, Juan Carlos; National University Autonomous of Mexico. Faculty of Dentistry. Immunology Laboratory. México
  • Andrade, Bruno Augusto; Federal University of Rio de Janeiro (UFRJ). School of Dentistry. Oral Pathology. Rio de Janeiro. Brazil
  • Romañach, Mário José; Federal University of Rio de Janeiro (UFRJ). School of Dentistry. Oral Pathology. Rio de Janeiro. Brazil
  • Mosqueda-Taylor, Adalberto; Universidad Autónoma Metropolitana. Health Care Department. Xochimilco. México
  • Carlos, Román; Hospital Herrera Llerandi. Centro Clínico de Cabeza y Cuello. Pathology Division. Guatemala City. Guatemala
  • Macedo, Madja Ruanna; Federal University of Rio Grande do Norte. Department of Nursing. Brazil
  • Almeida, Oslei Paes de; University of Campinas. Piracicaba Dental School. Area of Pathology. Departament of Oral Diagnosis. São Paulo. Brazil
  • Jorge, Jacks; University of Campinas. Piracicaba Dental School. Area of Pathology. Departament of Oral Diagnosis. São Paulo. Brazil
Med. oral patol. oral cir. bucal (Internet) ; Med. oral patol. oral cir. bucal (Ed.impr.);25(6): e728-e731, nov. 2020. ilus, tab
Article en En | IBECS | ID: ibc-197179
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT
BACKGROUND: Oral melanomas have some histopathological resemblance with its cutaneous counterpart; howev-er, an aggressive behavior is more common in tumors that occur in the oral cavity. Several markers have been suggested as indicative of tumoral progression and aggressiveness, such as cyclooxygenase 2 (COX-2) and Ki67. MATERIAL AND METHODS: In this study, we have compared the expression of COX-2 and Ki67 in a series of amelanotic (n = 7) and melanotic oral melanomas (n = 22). The cases were selected from 4 pathology laboratories and sub-mitted to the immunohistochemical (IHC) reactions. We analyzed the IHC staining based on a qualitative - using visual scores; and a computer-assisted method (quantitative) using scanned slides and software for digital analysis. RESULTS: COX-2 was expressed in all oral melanomas; however, its intensity was significantly higher in the amelanotic ones (P < 0.001). Similarly, a high Ki67-positivity index was observed in the amelanotic than melanotic ones (P < 0.001). CONCLUSIONS: Based on these results, we suggest that amelanotic oral melanomas have marked pro-inflammatory and high-proliferative phenotype, justifying their more aggressive behavior compared with the melanotic ones
RESUMEN
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Asunto(s)

Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Neoplasias de la Boca / Antígeno Ki-67 / Ciclooxigenasa 2 / Melanoma Límite: Female / Humans / Male Idioma: En Revista: Med. oral patol. oral cir. bucal (Ed.impr.) / Med. oral patol. oral cir. bucal (Internet) Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 06-national / ES Base de datos: IBECS Asunto principal: Neoplasias de la Boca / Antígeno Ki-67 / Ciclooxigenasa 2 / Melanoma Límite: Female / Humans / Male Idioma: En Revista: Med. oral patol. oral cir. bucal (Ed.impr.) / Med. oral patol. oral cir. bucal (Internet) Año: 2020 Tipo del documento: Article